High‑quality, highly specific recombinant allergens and monoclonal antibodies are indispensable tools for understanding the molecular mechanisms of allergic diseases, developing accurate diagnostic assays, and advancing novel immunotherapies. Among the many allergenic proteins and immunological reagents available today, 11S globulin seed storage protein , Der p 7 , Soy Allergen , and Art fr 5 stand out as critical reagents that enable precise identification of IgE‑mediated sensitisation, epitope mapping, and structure‑function studies of allergenic molecules. Produced in state‑of‑the‑art expression systems—including E. coli, HEK293, and CHO cells—with >95% purity, these recombinant proteins and antibodies offer defined molecular composition, batch‑to‑batch consistency, and formats tailored for diverse research applications. 11S globulin seed storage protein , Der p 7 , Soy Allergen , and Art fr 5 are now being applied across multiple cutting‑edge research and diagnostic areas, driving breakthroughs from component‑resolved diagnostics to allergen immunotherapy development.
11S Globulin Seed Storage Protein: A Major Food Allergen Family Across Legumes and Tree Nuts
11S globulin seed storage protein represents a family of large, soluble seed storage proteins present in various plants, including legumes (e.g., soybeans, peanuts) and tree nuts (e.g., cashews, almonds). These proteins serve as nutrient reserves for developing seeds and are major allergens due to their remarkable stability under heat and digestive conditions. Examples of 11S globulins include Ara h 3 (peanut), Gly m 6 (soy), and Ana o 2 (cashew), which trigger IgE‑mediated allergic reactions in susceptible individuals.
The Recombinant Anti-11S globulin seed storage protein Scfv is a rat monoclonal antibody produced in CHO cells with >95% purity and Protein A affinity purification. This reagent is ideal for studying the structural and functional properties of 11S globulins, developing immunoassays for food allergen detection, and investigating cross‑reactivity patterns across different plant species.
Der p 7: A Pan‑Allergen Bridging Dust Mite, Shellfish, and Cockroach Allergies
Der p 7 is an allergen from the house dust mite Dermatophagoides pteronyssinus, belonging to the tropomyosin family. Tropomyosins are highly conserved proteins across invertebrates, and Der p 7 is classified as a pan‑allergen—cross‑reacting with tropomyosins from other invertebrates such as shrimp and cockroaches. This cross‑reactivity has profound implications for allergy diagnosis and management, as sensitisation to Der p 7 may confer reactivity to multiple seemingly unrelated allergen sources.
The Recombinant Rabbit Anti-Der p 7 Monoclonal Antibody, clone AFD-WH9 is a rabbit monoclonal antibody produced in HEK293 cells with >95% purity and Protein A affinity purification. This antibody specifically recognises Der p 7, enabling researchers to investigate the molecular basis of cross‑reactivity between dust mite, shellfish, and cockroach allergies. It is an essential tool for developing component‑resolved diagnostic assays capable of distinguishing genuine sensitisation from cross‑reactive responses, and for evaluating novel immunotherapeutic strategies targeting pan‑allergens.
Soy Allergen: A Key Player in Food Allergy Research
Soy Allergen refers to a group of allergenic proteins found in soybeans (Glycine max). Major soy allergens include Gly m 4 (a profilin), Gly m 5 (a 7S globulin), and Gly m 6 (an 11S globulin). These proteins induce IgE‑mediated reactions—such as hives and vomiting—in both children and adults, although many children outgrow soy allergy. Cross‑reactivity with other legumes is also possible, adding further complexity to diagnosis and management.
The Recombinant Rabbit Anti-Soy Allergen Monoclonal Antibody is a rabbit monoclonal antibody produced in HEK293 cells. As food allergy prevalence continues to rise globally, reagents such as this are essential for advancing both fundamental research and clinical diagnostic capabilities.
Art fr 5: A Biological Marker for Pollen Allergy and Immunological Studies
Art fr 5 is a biological marker used in immunological research and diagnostics. It plays important roles in various cellular processes including cell signalling, adhesion, and activation. Pollen allergens from the Artemisia genus—commonly known as mugwort or wormwood—are among the most important triggers of respiratory allergic diseases worldwide. Component‑resolved diagnosis (CRD) techniques have been employed to simultaneously measure specific IgE levels against Artemisia allergens and their components. Recombinant Art fr 5 enables researchers to develop component‑resolved diagnostic assays for mugwort pollen allergy, investigate cross‑reactivity patterns with related allergens, and evaluate novel immunotherapeutic strategies.
Shared Advantages of Recombinant Allergens and Allergen‑Specific Antibodies
Recombinant allergens and allergen‑specific antibodies such as 11S globulin seed storage protein , Der p 7 , Soy Allergen , and Art fr 5 offer several distinct advantages over crude allergen extracts and unpurified biological materials:
· Defined molecular composition: Produced from cloned genes or hybridoma technologies, these reagents ensure consistent amino acid sequence, specificity, and biological activity across batches—eliminating the batch‑to‑batch variability inherent to natural extracts.
· High purity: Purification to >95% homogeneity removes contaminating proteins that can cause non‑specific binding or misleading diagnostic results.
· Multiple expression systems: Production in E. coli, HEK293, and CHO cells allows for proper folding, post‑translational modifications, and high‑yield expression tailored to specific application requirements.
· Versatile formats: Available as recombinant proteins (with His tags for convenient purification and detection) and monoclonal antibodies (scFv or full‑length IgG).
· Scalable production: Recombinant expression enables cost‑effective, large‑scale production to meet research and diagnostic demands.
· Comprehensive coverage: BOT Bioscience offers recombinant allergens and antibodies covering pollen, dust mite, food, animal dander, mold, and venom allergens.
How to Choose and Buy?
At BOT Bioscience , we are committed to providing premium‑quality recombinant allergens and allergen‑specific antibodies to support your cutting‑edge research in allergy, immunology, and diagnostics.
For researchers interested in exploring our allergen product portfolio, BOT Bioscience offers custom protein expression, antibody production, and conjugation services to meet your specific application requirements. Visit our Allergen page to explore the full range of products—from 11S globulin seed storage protein and Der p 7 to Soy Allergen , Art fr 5 , and beyond—and request a quote today.